It estimated that more than 800 million people suffer from mental disorders worldwide (WHO, 2017). Mental disorders are related to indicators such as decreased energy, depressed mood, loss of interest, feelings of guilt, poor concentration, sleeping troubles, and disturbed appetite. Mental disorders affect the quality of life, relationships, education, and work opportunities (Ferrari et al., 2013). The most common treatment for mental disorders includes pharmacotherapy and psychotherapy (Karyotaki et al., 2016; Khan et al., 2012), which, in the long term, can be expensive and costly for healthcare systems due to the prevalence of the disorder (Olfson et al., 2018). To address the health problem of mental disorders that affects so many people worldwide and effectively allocate health care spending, it is important to identify additional and effective treatment options. Physical activity and physical fitness are important factors that contribute to improving health. Regular physical activity reduces the risk of all-cause mortality and several chronic medical conditions, such as cardiovascular diseases, type 2 diabetes, all-cancer mortality, and hypertension (USDHHS, 2018). Furthermore, physical activity and physical fitness are also associated with mental health and depression (Marques et al., 2020). Therefore, physical activity can be considered a non-medication alternative to antidepressants (Blumenthal et al., 1999). We want to share our investigations to understand better the relationship between physical activity, physical fitness and mental disorders.